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Role of salivary matrix metalloproteinase-8 (MMP-8) in chronic periodontitis diagnosis
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《医学前沿(英文)》 2015年 第9卷 第1期 页码 72-76 doi: 10.1007/s11684-014-0347-x
Periodontitis is an inflammatory disease of the periodontium. Any imbalance between the matrix metalloproteinases (MMPs) secreted by neutrophils and tissue inhibitors initiates the destruction of collagen in gum tissue, leading to chronic periodontitis. This study aimed to correlate salivary levels of MMP-8 and periodontal parameters of chronic periodontitis to establish MMP-8 as a noninvasive marker for the early diagnosis of chronic periodontitis. The study involved 40 subjects visiting the periodontic OPD of Dr. Ziauddin Ahmad Dental College and Hospital, located in Aligarh, U.P., India, from 2011 to 2012. The subjects were divided into two groups: group I consisted of 20 periodontally healthy subjects (controls) while group II consisted of 20 patients with chronic periodontitis. Chronic periodontitis was assessed on the basis of several periodontal parameters, including pocket probing depth (PPD), clinical attachment level (CAL), gingival index (GI), and plaque index (PI). Around 3 ml of unstimulated and whole expectorated saliva was collected for MMP-8 estimation by ELISA using Quantikine human total MMP-8 immunoassay kits. Data were analyzed using STATISTICA (Windows version 6) software. Salivary MMP-8 levels of groups I and II were 190.91±143.89 ng/ml and 348.26±202.1 ng/ml, respectively. The MMP-8 levels and periodontal status (PPD, CAL, GI, and PI) of groups I and II showed positive and significant correlations (for PPD, r = 0.63, P<0.001; for CAL, r = 0.54, P<0.001; for GI, r = 0.49, P<0.001; and for PI, r = 0.63, P<0.001). The results of this study demonstrate elevated concentrations of MMP-8 in individuals with chronic periodontitis.
关键词: matrix metalloproteinase-8 chronic periodontitis pocket probing depth clinical attachment level gingival index plaque index
p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by
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《医学前沿(英文)》 2016年 第10卷 第3期 页码 320-329 doi: 10.1007/s11684-016-0463-x
Coronary atherosclerosis is a major complication of chronic kidney disease. This condition contributes to the increased mortality in dialysis patients. p-Cresyl sulfate (PCS) is a prototype of protein-bound uremic toxins that cannot be efficiently removed through routine dialysis procedures. In the present study, ApoE−/− mice that underwent 5/6 nephrectomy were randomly divided into two groups, namely, vehicle-treated group (n = 20) and PCS-treated group (n = 20). Mice were sacrificed for en face and immunohistological analyses after 8 or 24 weeks of high-fat diet. Rat aortic vascular smooth muscle cells (VSMCs) were treated with phosphate buffer solution or 500 µmol/L PCS for in vitro evaluation. PCS-treated mice were observed to suffer increased atherosclerotic lesions after eight weeks of PCS administration. Moreover, 24 weeks of PCS administration also markedly increased the vulnerability index of aortic plaques. PCS was also observed to facilitate the migration and proliferation of VSMCs during the progression of the disease. Moreover, PCS disturbed the balance between matrix metalloproteinases and tissue inhibitor of metalloproteinases within the plaques. Thus, PCS played a vital role in promoting atherogenesis and disturbing the stability of formed plaques probably by targeting VSMCs.
关键词: p-cresyl sulfate atherosclerosis plaque stability vascular smooth muscle cell
Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques
Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 36-42 doi: 10.1007/s11684-010-0020-y
关键词: vulnerable plaque animal models mechani-sm detection treatment
Research on port ecological suitability evaluation index system and evaluation model
Yaofeng XIE,Xia LV,Ru LIU,Liuyan MAO,Xiaoxi LIU
《结构与土木工程前沿(英文)》 2015年 第9卷 第1期 页码 65-70 doi: 10.1007/s11709-014-0258-6
关键词: port ecological suitability press-state-response (PSR) model evaluation index system
A total torque index for dynamic performance evaluation of a radial symmetric six-legged robot
Kejia LI, Xilun DING, Marco CECCARELL
《机械工程前沿(英文)》 2012年 第7卷 第2期 页码 219-230 doi: 10.1007/s11465-012-0320-9
This article focuses on the dynamic index and performance of a radial symmetric six-legged robot. At first the structure of the robot is described in brief and its inverse kinematics is presented. Then the dynamic model is formulated as based on the Lagrange equations. A novel index of total torque is proposed by considering the posture of the supporting legs. The new index can be used to optimize the leg’s structure and operation for consuming minimum power and avoiding unstable postures of the robot. A characterization of the proposed six-legged robot is obtained by a parametric analysis of robot performance through simulation using the presented dynamic model. Main influences are outlined as well as the usefulness of the proposed performance index.
Liang ZHU, Jingkang WANG
《化学科学与工程前沿(英文)》 2013年 第7卷 第3期 页码 322-328 doi: 10.1007/s11705-013-1348-z
关键词: tobramycin aminoglycoside refractive index detector high-performance liquid chromatography ion-pairing
《农业科学与工程前沿(英文)》 doi: 10.15302/J-FASE-2023521
● Score index methods readily discriminate genotypes adapted to a target environment.
关键词: Aerobic rice breeding selection drought resilience production capacity index resilience capacity index stress score index upland
SUSTAINABLE NITROGEN MANAGEMENT INDEX: DEFINITION, GLOBAL ASSESSMENT AND POTENTIAL IMPROVEMENTS
《农业科学与工程前沿(英文)》 2022年 第9卷 第3期 页码 356-365 doi: 10.15302/J-FASE-2022458
● A composite N management index is proposed to measure agriculture sustainability.
关键词: global assessment indicator nitrogen management sustainable agriculture sustainable development goals
K. Sathish KUMAR, T. JAYABARATHI
《能源前沿(英文)》 2012年 第6卷 第3期 页码 260-265 doi: 10.1007/s11708-012-0196-8
关键词: bacterial foraging optimization algorithm (BFOA) distribution system network reconfiguration load balancing index (LBI) radial network
Zhi-fang Zhou,Jing Ou,Sha-sha Wang,Xiao-hong Chen
《工程管理前沿(英文)》 2016年 第3卷 第1期 页码 9-17 doi: 10.15302/J-FEM-2016009
关键词: circular economy the papermaking enterprise material flow analysis value flow analysis evaluation index system
Can the Shanghai LNG Price Index indicate Chinese market?
Yeli ZENG, Cong DONG, Mikael HÖÖK, Jinhua SUN, Danyang SHI
《能源前沿(英文)》 2020年 第14卷 第4期 页码 726-739 doi: 10.1007/s11708-020-0701-4
关键词: liquefied natural gas price index Shanghai Petroleum and Gas Exchange price discovery market reforms
赵蔷,吴进军,夏鹏,王迪,刘丹,刘云,董晗
《中国工程科学》 2017年 第19卷 第3期 页码 13-19 doi: 10.15302/J-SSCAE-2017.03.003
本文围绕制造强国指标体系数据源、计算方式、指标归类等方面进行了完善优化研究,持续开展了年度指数测评工作及指数背后制造业发展态势的深入剖析。同时对2016年制造强国综合指数进行了预测算,总结了近五年的发展趋势,为制造强国发展进程提供了有益的参考。
郑立伟,张纲,蒋家东,王赟松
《中国工程科学》 2015年 第17卷 第7期 页码 76-75
本文构建了制造质量强国指标体系,分为质量安全、质量发展和质量基础三个维度,建立了11个评价指标。通过实证分析将我国制造业产品质量与部分国家进行了比较,并分析了我国制造业质量水平变化的趋势。结论表明:我国制造业质量经历了一个稳步提升的过程,2008年金融危机后提升幅度明显下降;与新兴制造国家相比,我国产品质量表现出一定优势;与发达国家相比,仍存在安全、性能差距,影响了我国制造业的出口贸易。
Pavement sustainability index for highway infrastructures: A case study of Maryland
Stella O. OBAZEE-IGBINEDION, Oludare OWOLABI
《结构与土木工程前沿(英文)》 2018年 第12卷 第2期 页码 192-200 doi: 10.1007/s11709-017-0413-y
关键词: pavement indices sustainability pavement performance flexible pavements
刘爱华,施式亮,吴超
《中国工程科学》 2006年 第8卷 第9期 页码 90-94
针对高层建筑火灾危险的特点, 通过对火灾场景的设定,从消防对策的角度对火灾进行了阶段划分,并针对每个阶段运用了事故树和事件树的方法进行了事故分析,找出了影响火灾发展和蔓延的相关因素,建立了多层次的高层建筑火灾危险评价的指标体系。该指标体系能为建筑物安全管理提供科学依据,也能为高层建筑火灾风险评估奠定基础。
标题 作者 时间 类型 操作
p-Cresyl sulfate promotes the formation of atherosclerotic lesions and induces plaque instability by
null
期刊论文
Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques
Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,
期刊论文
Research on port ecological suitability evaluation index system and evaluation model
Yaofeng XIE,Xia LV,Ru LIU,Liuyan MAO,Xiaoxi LIU
期刊论文
A total torque index for dynamic performance evaluation of a radial symmetric six-legged robot
Kejia LI, Xilun DING, Marco CECCARELL
期刊论文
determination of tobramycin by reversed-phase ion-pair high performance liquid chromatography with a refractive index
Liang ZHU, Jingkang WANG
期刊论文
Isolating higher yielding and more stable rice genotypes in stress environments: fine-tuning a selection method using production and resilience score indices
期刊论文
SUSTAINABLE NITROGEN MANAGEMENT INDEX: DEFINITION, GLOBAL ASSESSMENT AND POTENTIAL IMPROVEMENTS
期刊论文
A novel power system reconfiguration for a distribution system with minimum load balancing index using
K. Sathish KUMAR, T. JAYABARATHI
期刊论文
The Building of Papermaking Enterprise’s Recycling Economy Evaluation Index System Based on Value Flow
Zhi-fang Zhou,Jing Ou,Sha-sha Wang,Xiao-hong Chen
期刊论文
Can the Shanghai LNG Price Index indicate Chinese market?
Yeli ZENG, Cong DONG, Mikael HÖÖK, Jinhua SUN, Danyang SHI
期刊论文
Pavement sustainability index for highway infrastructures: A case study of Maryland
Stella O. OBAZEE-IGBINEDION, Oludare OWOLABI
期刊论文